I personally would wait until after the break in to run synthetic oil, until the rings seat well, you get gas and all sorts of stuff in your oil. Seems like a waste of money to run synthetic at that point.
As a side light, I had a friend that used to be a factory mechanic for Honda RC45's. He claimed that they couldn't get the engines to break in correctly with synthetic oils (they were too good). So they would break them in with dino and then switch over to synthetic for the races.
I don't know if he was being truthful or not, but he did get me into meet Miguel Duhamel, back when he was racing for the Smoking Joe's team so I feel like I have to believe him.
