Welcome to the boards and congrats on your purchase!
Here's a couple of responses to your questions:
Regular vs. Premium has been discussed here quite a few times. It's about split down the middle as to whether it helps or not. I say unless you're putting a tune on the truck (UpRev Osiris) or similar, run the regular. I run premium when I'm towing, just to be safe in trying to keep pre detonation to a minimum.
I personally haven't read any negatives on the 2*. I've had that done on mine and really liked the better response I seem to have. Especially from a rolling speed to going heavy on the gas, such as to overtake another vehicle.