Let's assume your wife's Titan has standard transmission gears (1st - 3.827, 2nd - 2.368, 3rd - 1.519, 4th - 1.000, 5th - 0.834). Further, assume she has the standard rear axle ratio of 2.940.
Since she has 245/75-17 tires, the standard diameter would be about 31.470 inches. At 1500 rpm, she SHOULD be doing 47.77 MPH in 4th gear. Close enough to 48 MPH.
Let's assume YOUR Titan has the Big Tow package with 3.357 rear axle. Your transmission has the same gears and you are running 265/75-18 tires with a nominal tire diameter of 33.650 inches. At 1500 RPM in 4th gear, you SHOULD be running 44.73 MPH. Close enough to 45 MPH.
So, I see maybe a 3 MPH difference, 4 at the outside, assuming your tachometers are correct and your kept constant throttle when you switched to the speedometer from the tachometer. If you went a little fast in hers and little slow in yours, then you are pretty close to what you saw.
It would be more accurate to run side by side at the same speed in the same gear. Ask her to note the RPM and you do the same. We could go from there.