U-joints are on the drive shafts, and there are 2 on each one. You would probably hear a clicking type noise more than a grinding noise. Or if they are real bad you would have a bang every time you pushed the accelerator. I had one of my front drive shaft U-joints go out.
CV joints or constant velocity joints are on your front shafts that go to your front tires (if you have 4wd) and have a rubber boot on both sides. Those would make a noise, but usually only when you turn.
Just get under the truck and try to turn the drive shafts by hand. And look for a joint at the front and the back of the shaft to see if there is any play in them. If you can see any play they are bad. Don't get them from Nissan, they are like 70 bucks a piece autozone they are 8 bucks a piece.